Andrew Henry was born in Pennsylvania in 1775 & came to Ste. Genevieve & the lead mines of Washington County Missouri from Tennessee in 1800. Henry served as justice of the peace & was a trustee for the Ste. Genevieve Academy. A few years later he & William H. Ashley purchased 640 acres in the mining district of Washington County which was known as Henry's Diggins. In 1805 Andrew Henry married Marie Villars of Ste. Genevieve but the short-lived marriage of three weeks did produce one daughter. In 1806 Henry bought out Ashley's half of the mine. He went to St. Louis & in 1809 he, along with Jean Pierre Chouteau & William Clark (of Lewis & Clark fame) founded the Missouri Fur Company. In 1810 on expeditions to Montana & Idaho Henry's men that included Pierre Menard & John Colter (of Colter's Hell fame) discovered Lake Henry & spent the winter on Henry's Fork where they established Fort Henry.
Henry participated in the War of 1812 & held the rank of major. In 1818 he married again & eventually became the father of four children one of which was a daughter named Mary Jane (b:1820) who married Robert Cain, Jr. In 1822 Henry, along with William H. Ashley, founded the Rocky Mountain Fur Company & was associated with the famous mountain men Jim Bridger, Jedediah Smith, Kit Carson & led them on fur trapping expeditions. Henry was a skilled woodsman, fur trader & explorer. In 1824, after a good year, Henry returned to Missouri & the lead industry. He is listed on the 1830 Washington County, Missouri census in Black River Township (now part of Iron County) where he had a farm. He is the only Henry listed in the 1830 Washington County census. Henry died at this farm 10 June 1833. In the 1840 census his widow, Mary, is living in Concord Township of Washington County. Also a William Henry is living in Liberty Township. In 1850 Mary is living with her daughter & son-in-law Jane & Robert Cain in Washington County.